|
KMID : 1134820120410081106
|
|
Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 8 p.1106 ~ p.1111
|
|
|
Vitamin E in vivo Studies on the Activity of Antioxidant Enzymes and CYP2E1 Expression in High PUFA-treated Brains
|
|
Choi Mun-Ji
Kim Hyun-Kyung
Lee Myoung-Sook
|
|
|
Abstract
|
|
|
|
It is shown that the risk of chronic disease is increased not only by the concentration of fat in the diet but also by the composition of dietary fatty acids. We investigated the anti-oxidant effects of vitamin E on dietary polyunsaturated fatty acid-fed mice. Ninety male Sprague-Dawley rats were randomly divided into 9 groups: a normal diet group (C), 4 dietary polyunsaturated fatty acid diet groups (OA, LA, LNA, DHA), and 4 dietary polyunsaturated fatty acid diet with 0.05% vitamin E groups (OAE, LAE, LNAE, DHAE). The food efficiency in the dietary polyunsaturated fatty acid diet groups was higher than in the normal diet groups. The concentration of malondialdehyde (MDA) was significantly increased by LA and DHA fatty acids. Vitamin E significantly decreased LA and LHA-induced lipid peroxidation. The activity of superoxide dismutase and glutathione peroxidase was increased in the dietary polyunsaturated fatty acid diet groups compared to the control group, while these were decreased by supplements with vitamin E, except in the OAE group. Also, the protein expression of CYP2E1 was significantly increased in only the LNA group, while these were decreased by supplements with vitamin E. These results taken together indicate that vitamin E may have positive effects on a dietary polyunsaturated fatty acid diet-induced oxidative stress in brain tissue.
|
|
|
KEYWORD
|
|
|
dietary polyunsaturated fatty acid, vitamin E, oxidative stress, brain
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|